Inhibitory effect of Di- and trihydroxy triterpenes from the flowers of compositae on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice.

Abstract

Ten dihydroxy- and trihydroxy triterpenes, viz., four taraxastanes: faradiol, heliantriol B0, heliantriol C and arnidiol; two lupanes: calenduladiol and heliantriol B2; two oleananes: maniladiol and longispinogenin; and two ursanes: brein and uvaol, isolated from the nonsaponifiable lipids of the flower extracts of Compositae plants were evaluated with respect to their anti-inflammatory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. All the triterpenes were found to possess marked inhibitory activity. The 50% inhibitory dose of these compounds with respect to TPA-inflammation (1 microgram) was 0.03-0.2 mg/ear.

• Authors: K Yasukawa, T Akihisa, H Oinuma, Y Kasahara, Y Kimura, S Yamanouchi, K Kumaki, T Tamura, M Takido
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 19 Issue 10 Pg. 1329-31 (Oct 1996) ISSN: 0918-6158 [Print] Japan
• PMID: 8913506 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Triterpenes
• Tetradecanoylphorbol Acetate

Topics

• Animals
• Inflammation (chemically induced)
• Mice
• Plants
• Tetradecanoylphorbol Acetate (antagonists & inhibitors, pharmacology)
• Triterpenes (chemical synthesis, pharmacology)