Abstract | BACKGROUND:
Autistic disorder is characterized by a fundamental disturbance in social interaction, impairments in communication, and a markedly restricted repertoire of activities and interests. Abnormalities in the serotonin neurotransmitter system have been identified in some persons with autism. No consistently effective and safe drugs have been developed for treating the symptoms of autism. METHODS: RESULTS: Eight (53%) of 15 patients in the fluvoxamine-treated group were categorized as responders compared with none of 15 in the placebo group (P = .001). Fluvoxamine was superior to placebo in reducing repetitive thoughts and behavior (P < .001), maladaptive behavior (P < .001), and aggression (P < .03), and in improving some aspects of social relatedness (P < .04), especially language usage (P < .008). Treatment response was not correlated with age level of autistic behavior, or full-scale IQ. Other than mild sedation and nausea in a few patients, fluvoxamine was well tolerated. No dyskinesias, adverse cardiovascular events, or seizures occurred. CONCLUSIONS:
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Authors | C J McDougle, S T Naylor, D J Cohen, F R Volkmar, G R Heninger, L H Price |
Journal | Archives of general psychiatry
(Arch Gen Psychiatry)
Vol. 53
Issue 11
Pg. 1001-8
(Nov 1996)
ISSN: 0003-990X [Print] United States |
PMID | 8911223
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Placebos
- Serotonin Uptake Inhibitors
- Fluvoxamine
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Topics |
- Adolescent
- Adult
- Autistic Disorder
(diagnosis, drug therapy, psychology)
- Double-Blind Method
- Female
- Fluvoxamine
(therapeutic use)
- Humans
- Male
- Middle Aged
- Placebos
- Psychiatric Status Rating Scales
- Selective Serotonin Reuptake Inhibitors
(therapeutic use)
- Treatment Outcome
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