Expression of oncogene products, anti-oncogene products and oncofetal antigens in intraductal papillary-mucinous neoplasm of the pancreas.

Abstract

A few previous studies have demonstrated the expression or mutations of oncogenes and anti-oncogenes as well as that of oncofetal antigens in intraductal papillary-mucinous neoplasm of the pancreas. In this study, we have investigated the immunohistochemical expression of oncogene (ras and c-erbB-2) and anti-oncogene (p53 and retinoblastoma [Rb]) products and oncofetal antigens (CEA, CA19-9 and DUPAN-2) in nine such tumours of the pancreas. In normal pancreas (5 cases), the Rb gene product and CA19-9 were expressed in all cases, while ras and c-erbB-2 gene products, p53 protein, CEA and DUPAN-2 were not expressed. In intraductal papillary-mucinous tumours (n = 9), ras, c-erbB-2, p53 and Rb gene products were present in 4/9 (44%), 7/9 (78%), 0.9 (0%) and 6/9 (67%) cases, respectively. CEA, CA19-9 and DUPAN-2 were expressed in 8/9 (89%), 9/9 (100%) and 2/9 (22%) cases respectively. In invasive ductal adenocarcinoma of the pancrease (7 cases), ras, c-erbB-2, p53 and Rb gene products were expressed in 3/7 (43%), 6/7 (86%), 2/7 (29%) and 3/& (43%) cases respectively. CEA, CA19-9 and DUPAN-2 were expressed in 7/7 (100%), 7/7 (100%) and 6/7 (86%) cases, respectively. The extent and intensity of the expression of these antigens was greater in invasive ductal adenocarcinomas. These data suggest that activation of ras and c-erbB-2 oncogenes and inactivation of Rb anti-oncogene may contribute to the development and progression of intraductal papillary-mucinous tumours of the pancreas and that there is neo-expression of CEA and DUPAN-2 during the development and progression of these tumours.

• Authors: T Terada, T Ohta, Y Nakanuma
• Journal: Histopathology (Histopathology) Vol. 29 Issue 4 Pg. 355-61 (Oct 1996) ISSN: 0309-0167 [Print] England
• PMID: 8910043 (Publication Type: Journal Article)

Chemical References

• Antigens, Neoplasm
• Biomarkers, Tumor
• CA-19-9 Antigen
• Carcinoembryonic Antigen
• DU-PAN-2 antigen, human
• Neoplasm Proteins
• Oncogene Proteins
• Proto-Oncogene Proteins
• Tumor Suppressor Protein p53
• Receptor, ErbB-2
• ras Proteins

Topics

• Adenocarcinoma, Mucinous (genetics, metabolism, pathology)
• Antigens, Neoplasm (metabolism)
• Biomarkers, Tumor (metabolism)
• CA-19-9 Antigen (metabolism)
• Carcinoembryonic Antigen (metabolism)
• Carcinoma, Papillary (genetics, metabolism, pathology)
• Genes, Retinoblastoma
• Humans
• Immunohistochemistry
• Neoplasm Proteins (metabolism)
• Oncogene Proteins (metabolism)
• Pancreatic Neoplasms (genetics, metabolism, pathology)
• Proto-Oncogene Proteins (metabolism)
• Receptor, ErbB-2 (metabolism)
• Tumor Suppressor Protein p53 (metabolism)
• ras Proteins (metabolism)