Abstract |
Chlorinated phenols are widely used in the manufacture of biocides and wood preservatives. 2,4-dichlorophenol administered perorally 3 times a week at a dose of 40 mg in 0.2 ml of olive oil per kg of body weight to guinea pigs increased lipid peroxidation in liver and adrenals after 2 weeks of treatment. A high intake of ascorbic acid (50 mg/animal/day) significantly decreased lipid peroxidation in the liver of 2, 4-dichlorophenol treated guinea pigs in comparison to guinea pigs with low ascorbic acid intake (2 mg/animal/day). 2,4-dichlorophenol accumulation was also decreased in the liver of animals with high ascorbic acid intake. Increased daily intake of vitamin C to persons involved in production and use of chlorophenoxy herbicides is recommended.
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Authors | D Clerhata, Z Kováciková, M Veningerová, M Lukácsová, E Ginter |
Journal | Industrial health
(Ind Health)
Vol. 34
Issue 4
Pg. 415-9
( 1996)
ISSN: 0019-8366 [Print] Japan |
PMID | 8908852
(Publication Type: Journal Article)
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Chemical References |
- Chlorophenols
- Ascorbic Acid
- 2,4-dichlorophenol
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Topics |
- Adrenal Glands
(metabolism)
- Analysis of Variance
- Animals
- Ascorbic Acid
(pharmacology)
- Chlorophenols
(pharmacology)
- Guinea Pigs
- Lipid Peroxidation
(drug effects)
- Liver
(metabolism)
- Male
- Regression Analysis
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