Abstract |
The kinetic profiles of norfloxacin were evaluated in afebrile, febrile and probenecid pre-treated (70 mg/kg orally) febrile goats after a single intravenous (i.v.) dose (5 mg/kg). Fever was induced and maintained for 12 h by injecting Escherichia coli endotoxin (0.2 microgram/kg, i.v.) and repeating it in half the dose (0.1 microgram/kg) 5 h later. The plasma pharmacokinetic values for norfloxacin were best represented using a two-compartment open model. The peak norfloxacin plasma level of 90.52 +/- 3.18 micrograms/ml attained in the probenecid pre-treated febrile goats was higher than that in the febrile (75.46 +/- 0.72 micrograms/ml) or afebrile goats (62.25 +/- 1.23 micrograms/ml). ClB and Kel values were significantly (p < 0.01) decreased in febrile compared with afebrile goats. These values were further reduced in febrile goats after probenecid pre-treatment. However, t1/2 beta was not affected by the fever- probenecid interaction. Norfloxacin may be used as an infusion with probenecid in caprine diseases where very high plasma levels are required to combat resistant organisms such as Bacteroides.
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Authors | K Jha, B K Roy, R C Singh |
Journal | Veterinary research communications
(Vet Res Commun)
Vol. 20
Issue 5
Pg. 473-9
( 1996)
ISSN: 0165-7380 [Print] Netherlands |
PMID | 8908728
(Publication Type: Journal Article)
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Chemical References |
- Endotoxins
- Lipopolysaccharides
- Norfloxacin
- Probenecid
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Topics |
- Analysis of Variance
- Animals
- Drug Interactions
- Endotoxins
- Escherichia coli
- Female
- Fever
(physiopathology)
- Goats
- Lipopolysaccharides
- Metabolic Clearance Rate
- Models, Biological
- Norfloxacin
(blood, pharmacokinetics)
- Probenecid
(pharmacology)
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