The efficacy and pharmacokinetics of long-term low-level intraruminal administration of triclabendazole in buffalo with induced fasciolosis.

Abstract

A study was conducted on the pharmacokinetics and therapeutic efficacy of triclabendazole at three low dose rates of 0.5, 1.0 and 1.5 mg/kg body weight in buffaloes experimentally infected with Fasciola gigantica. The pharmacokinetics were compared with the effects of a single intraruminal dose at 24.0 mg/kg body weight in uninfected buffaloes. At all three dose rates, an equilibrium between the absorption of triclabendazole and the disposition of its metabolites was observed by days 3 and 4 and remained almost unchanged thereafter. Continuous daily dosing at 1.5 mg/kg body weight proved to be efficacious against liver fluke infection in buffaloes.

• Authors: P K Sanyal, S C Gupta
• Journal: Veterinary research communications (Vet Res Commun) Vol. 20 Issue 5 Pg. 461-8 ( 1996) ISSN: 0165-7380 [Print] Netherlands
• PMID: 8908726 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anthelmintics
• Benzimidazoles
• Triclabendazole

Topics

• Animals
• Anthelmintics (administration & dosage, pharmacokinetics, therapeutic use)
• Benzimidazoles (administration & dosage, pharmacokinetics, therapeutic use)
• Biotransformation
• Buffaloes
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Fascioliasis (drug therapy)
• Injections
• Male
• Metabolic Clearance Rate
• Rumen
• Triclabendazole