[Clinical pilot study of the myogenic effects of flupirtine in comparison to tetrazepam and placebo].

Abstract

The effects of flupirtine (CAS 56995-20-1, D-9998, Katadolon) on muscle force and related electromyographic (EMG) activity has been assessed in comparison to tetrazepam and placebo in 12 healthy male volunteers after oral single-dose administration and under steady-state conditions. Muscle functions primarily reflecting dynamic daily demands remained unaffected under flupirtine in contrast to tetrazepam, the latter exhibiting the typical signs of increased (co-)innervation which can be interpreted as a compensation of a decrease of muscle force. Under conditions that serve as a model for static-spastic situations, flupirtine showed a decrease, tetrazepam a typical increase in the force parameter. Under the same conditions, a decrease of the EMG-amplitude was observed for flupirtine and, to a lesser extent, for tetrazepam as well. With respect to its muscle relaxing property, flupirtine differs both, quantitatively and qualitatively from tetrazepam, which has shown effects common for benzodiazepines.

• Authors: M Lobisch, K Schaffler, H Wauschkuhn, B Nickel
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 46 Issue 3 Pg. 293-8 (Mar 1996) ISSN: 0004-4172 [Print] Germany
• Vernacular Title: Klinische Pilotstudie zur myogenen Wirkung von Flupirtin im Vergleich zu Tetrazepam und Plazebo.
• PMID: 8901152 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article)

Chemical References

• Aminopyridines
• Anti-Anxiety Agents
• Benzodiazepinones
• Muscle Relaxants, Central
• Neuroprotective Agents
• Benzodiazepines
• tetrazepam
• flupirtine

Topics

• Adult
• Aminopyridines (pharmacology)
• Anti-Anxiety Agents
• Benzodiazepines
• Benzodiazepinones (pharmacology)
• Electromyography (drug effects)
• H-Reflex (drug effects)
• Humans
• Isometric Contraction (drug effects)
• Male
• Middle Aged
• Muscle Contraction (drug effects)
• Muscle Relaxants, Central (pharmacology)
• Muscle, Skeletal (drug effects)
• Neuroprotective Agents (pharmacology)
• Pilot Projects