Plasma N tau-methylhistidine concentration is a sensitive index of myofibrillar protein degradation during starvation in rats.

Abstract

Urinary excretion of N tau-methylhistidine (MeHis) in rats was linearly elevated by starvation for 2 days. Plasma concentration of MeHis on day 1 and day 2 of starvation were increased 2.4- and 2.6-fold, respectively. The amount of released MeHis from the isolated muscles into medium during a 2-h incubation period was increased with starvation corresponded to the plasma MeHis concentration. The results of this study suggest that plasma MeHis is a sensitive index of myofibrillar protein degradation.

• Authors: T Nagasawa, F Yoshizawa, N Nishizawa
• Journal: Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 60 Issue 3 Pg. 501-2 (Mar 1996) ISSN: 0916-8451 [Print] England
• PMID: 8901113 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Methylhistidines
• Muscle Proteins
• 3-methylhistidine

Topics

• Animals
• Body Weight (physiology)
• Methylhistidines (blood, urine)
• Muscle Proteins (metabolism)
• Muscles (anatomy & histology, metabolism)
• Organ Size (physiology)
• Rats
• Rats, Sprague-Dawley
• Sensitivity and Specificity
• Starvation (blood, metabolism, urine)