Abstract | BACKGROUND AND PURPOSE: METHODS: We investigated the common carotid and carotid bifurcation IMTs and their determinants in groups of elderly patients (n = 84, age 67.2 +/- 0.6 years) with NIDDM and in 119 control subjects (21 with impaired and 98 with normal glucose tolerance; ages 67.5 +/- 1.0 and 65.1 +/- 0.6 years, respectively). RESULTS: Common carotid and carotid bifurcation IMTs were greater in the NIDDM group than in control subjects (P < .05 to .01). In NIDDM patients, the mean carotid IMT correlated with postglucose 1-hour plasma insulin (r = .305, P = .01, adjusted for age and sex), serum LDL triglyceride (r = .237, P < .05), and apolipoprotein B concentrations (r = .263, P < .05). Fasting plasma immunoreactive insulin, proinsulin, or specific insulin levels were not significantly associated with carotid IMT. Both diabetic status (P < .05) and the presence of clinical macrovascular disease (P < .01) contributed independently to carotid IMT. CONCLUSIONS: Carotid IMT was greater in NIDDM patients than in control subjects. The main determinants of IMT in NIDDM patients were related to both postglucose insulin levels and abnormal lipoprotein profiles characteristic of NIDDM and insulin resistance syndrome. Treatment of these factors is likely to reduce the atherosclerotic burden in NIDDM.
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Authors | L Niskanen, R Rauramaa, H Miettinen, S M Haffner, M Mercuri, M Uusitupa |
Journal | Stroke
(Stroke)
Vol. 27
Issue 11
Pg. 1986-92
(Nov 1996)
ISSN: 0039-2499 [Print] United States |
PMID | 8898803
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Insulin
- Lipids
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Topics |
- Aged
- Analysis of Variance
- Blood Glucose
(metabolism)
- Cardiovascular Diseases
(etiology)
- Carotid Arteries
(diagnostic imaging, pathology)
- Carotid Artery, Common
(pathology)
- Carotid Stenosis
(complications, pathology)
- Cross-Sectional Studies
- Diabetes Mellitus, Type 2
(blood, complications, pathology)
- Female
- Follow-Up Studies
- Humans
- Insulin
(blood)
- Lipids
(blood)
- Logistic Models
- Male
- Middle Aged
- Risk Factors
- Sex Factors
- Tunica Intima
(pathology)
- Tunica Media
(pathology)
- Ultrasonography
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