Resistance to activated protein C (APC) in Indian patients of thrombophilia.

Abstract

In a pilot study, 28 consecutive patients with thrombosis and 23 age and sex matched healthy normal controls were investigated with normalised APC sensitivity ratio (n-APC-SR) to know the defect exists and if so its prevalence in India. Six of the 28 (21.4%) thrombotic patients had n-APC-SR of < 0.76 (range 0.55 to 0.74) as compared to the normal control value (0.97 +/- 0.105). Our study shows APC resistance defect in a significant proportion (21.4%) of Indian patients with thrombotic disorders.

• Authors: H P Pati, A Srivastava, S Dayal
• Journal: The Indian journal of medical research (Indian J Med Res) Vol. 104 Pg. 213-5 (Sep 1996) ISSN: 0971-5916 [Print] India
• PMID: 8898480 (Publication Type: Journal Article)

Chemical References

• Protein C

Topics

• Adolescent
• Adult
• Case-Control Studies
• Child
• Disease Susceptibility
• Enzyme Activation
• Female
• Humans
• India
• Male
• Middle Aged
• Protein C (metabolism)
• Thrombosis (blood)