Evaluation of the effect of ketoprofen on experimentally induced ephemeral fever in dairy heifers.

Abstract

OBJECTIVE:

To evaluate ketoprofen for the therapy of ephemeral fever.

DESIGN:

A blind controlled clinical trial.

ANIMALS:

Sixteen cattle (one immature Holstein bull, eight Holstein and seven Jersey heifers).

PROCEDURE:

Ephemeral fever was induced by the intravenous injection of blood leucocyte layer from a clinical case. Ketoprofen solution or a coded placebo was injected intramuscularly at the rate of 3 mg/kg daily for three days.

RESULTS:

Ketoprofen reversed locomotor dysfunctions significantly compared with controls, but did not have any effect on rectal temperatures, leucocyte counts, plasma fibrinogen concentrations, ionised Ca-concentrations or the presence of dyspnoea.

CONCLUSION:

Ketoprofen is a safe and effective drug for the treatment of locomotor symptoms of milk fever, but has no effect on the duration of clinical respiratory abnormalities.

• Authors: D C Fenwick, R C Daniel
• Journal: Australian veterinary journal (Aust Vet J) Vol. 74 Issue 1 Pg. 37-41 (Jul 1996) ISSN: 0005-0423 [Print] England
• PMID: 8894003 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Fibrinogen
• Ketoprofen
• Calcium

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology, therapeutic use)
• Body Temperature
• Body Weight (drug effects)
• Calcium (blood)
• Cattle
• Ephemeral Fever (complications, drug therapy, physiopathology)
• Female
• Fibrinogen (metabolism)
• Ketoprofen (pharmacology, therapeutic use)
• Lameness, Animal (drug therapy, etiology)
• Leukocyte Count (veterinary)
• Locomotion (drug effects)
• Male
• Respiration (drug effects)
• Starvation (drug therapy, etiology, veterinary)
• Tremor (drug therapy, etiology, veterinary)