| Abstract | The purified recombinant V antigen from Yersinia pestis, expressed in Escherichia coli and adsorbed to aluminum hydroxide, an adjuvant approved for human use, was used to immunize outbred Hsd:ND4 mice subcutaneously. Immunization protected mice from lethal bubonic and pneumonic plague caused by CO92, a wild-type F1+ strain, or by the isogenic F1- strain C12. This work demonstrates that a subunit plague vaccine formulated for human use provides significant protection against bubonic plague caused by an F1- strain (C12) or against substantial aerosol challenges from either F1+ (CO92) or F1-(C12) Y. pestis. |
| Authors | G W Anderson Jr, S E Leary, E D Williamson, R W Titball, S L Welkos, P L Worsham, A M Friedlander
(Affiliation: United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702-5011, USA. LTC_george_anderson at ftdetrck-ccmail.army.mil.)
|
| Journal | Infection and immunity
(Infect Immun)
Vol. 64
Issue 11
Pg. 4580-5
(Nov 1996)
ISSN: 0019-9567 UNITED STATES |
| PMID | 8890210
(Publication Type: Journal Article)
|
| Chemical References |
- Antibodies, Bacterial
- Antigens, Bacterial
- Bacterial Capsules
- Immunoglobulin G
- LcrV protein, Yersinia
- Plague Vaccine
- Pore Forming Cytotoxic Proteins
- Vaccines, Synthetic
|
| Topics |
- Animals
- Antibodies, Bacterial
(biosynthesis, blood)
- Antigens, Bacterial
(immunology)
- Bacterial Capsules
(analysis)
- Enzyme-Linked Immunosorbent Assay
- Female
- Immunoglobulin G
(biosynthesis, blood)
- Mice
- Plague
(microbiology, prevention & control)
- Plague Vaccine
(immunology)
- Pore Forming Cytotoxic Proteins
- Vaccination
- Vaccines, Synthetic
(immunology)
- Yersinia pestis
(immunology)
|
