Abstract | BACKGROUND: The addition of dextran with a molecular weight of 40,000 Dalton in pulmonary preservation solutions has proved to be beneficial. However, dextrans of other size have not yet been investigated. Therefore, it is unclear whether dextran 40,000 represents the optimal additive for lung preservation solutions. METHOD: In a working rat heart-lung model, lung were preserved with regular Euro-Collins solution or with Euro-Collins solution containing 5% dextran of different sizes: 40,000 Dalton molecular weight; 70,000 Dalton molecular weight; 160,000 Dalton molecular weight. After 2 hours of ischemia functional (oxygenation; pulmonary vascular resistance) and structural (wet/dry-ratio, light microscopy) data were assessed and the amount of dextran in the lung tissue was measured. RESULTS: CONCLUSIONS:
Dextrans are useful additives for lung preservation solutions. However, the size of the molecules is important because dextrans of 160,000 Dalton molecular weight were superior to dextrans of lower molecular weight in our study.
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Authors | T Fukuse, J M Albes, A Wilhelm, T Bando, F Fischer, B Hausen, R Rohde, T Wahlers, H J Schäfers |
Journal | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
(J Heart Lung Transplant)
Vol. 15
Issue 9
Pg. 903-10
(Sep 1996)
ISSN: 1053-2498 [Print] United States |
PMID | 8889986
(Publication Type: Journal Article)
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Chemical References |
- Anticoagulants
- Dextrans
- Euro-Collins' solution
- Hypertonic Solutions
- Organ Preservation Solutions
- Plasma Substitutes
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Topics |
- Animals
- Anticoagulants
- Dextrans
- Hypertonic Solutions
- Lung
(anatomy & histology)
- Lung Transplantation
(physiology)
- Lung Volume Measurements
- Male
- Molecular Weight
- Organ Preservation Solutions
- Organ Size
- Plasma Substitutes
- Rats
- Rats, Sprague-Dawley
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