pros-Methylimidazoleacetic acid in cerebrospinal fluid of patients with chronic schizophrenia: relationships to ratings of symptoms, ventricular brain ratios, and rates of urine excretion.

Abstract

Concentrations of pros-methylimidazoleacetic acid (p-MIAA) were measured in cerebrospinal fluid of 30 patients with chronic schizophrenia. Levels of p-MIAA correlated negatively with mean scores of the Psychiatric Symptom Assessment Scale for positive symptoms (r = -0.48), but not negative symptoms, and with ventricular brain ratios (r = -0.48). Patients with abnormal ventricular enlargements had much lower concentrations of p-MIAA than those with normal ventricles. These results suggest that processes that reduce accumulation of p-MIAA in CSF may be associated with increased severity of symptoms among patients with chronic schizophrenia.

• Authors: G D Prell, J P Green, J K Khandelwal, R J Wyatt, W B Lawson, A C Jaeger, C A Kaufmann, D G Kirch
• Journal: Clinical neuropharmacology (Clin Neuropharmacol) Vol. 19 Issue 5 Pg. 415-9 (Oct 1996) ISSN: 0362-5664 [Print] United States
• PMID: 8889284 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Imidazoles
• methylimidazoleacetic acid

Topics

• Adult
• Cerebral Ventricles (metabolism)
• Chronic Disease
• Female
• Humans
• Imidazoles (cerebrospinal fluid)
• Male
• Middle Aged
• Psychiatric Status Rating Scales
• Regression Analysis
• Schizophrenia (cerebrospinal fluid, urine)
• Urine