Abstract |
The effect of majonoside-R2 on morphine- and U-50,488H-induced antinociception was examined by the tail-pinch test in mice and compared with that of diazepam. Majonoside-R2 and diazepam inhibited the morphine- and U-50,488H-induced antinociception, and the actions were antagonized by the benzodiazepine receptor antagonist flumazenil and the GABA-gated CI- channel blocker picrotoxin. Diazepam but not majonoside-R2 exhibited a protective activity against convulsion caused by the GABAA antagonists bicuculline and picrotoxin. These results indicate that GABAA systems are involved in the effect of majonoside-R2 on the opioid-induced antinociception and suggest that the mechanisms of action of majonoside-R2 may differ from those of diazepam.
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Authors | T T Nguyen, K Matsumoto, K Yamasaki, M D Nguyen, T N Nguyen, H Watanabe |
Journal | Japanese journal of pharmacology
(Jpn J Pharmacol)
Vol. 71
Issue 4
Pg. 345-9
(Aug 1996)
ISSN: 0021-5198 [Print] Japan |
PMID | 8886934
(Publication Type: Journal Article)
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Chemical References |
- Analgesics
- Analgesics, Opioid
- Convulsants
- GABA Modulators
- Ginsenosides
- Pyrrolidines
- Saponins
- Picrotoxin
- Flumazenil
- 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
- Morphine
- majonoside R2
- Diazepam
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Topics |
- 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
- Analgesics
(antagonists & inhibitors)
- Analgesics, Opioid
(antagonists & inhibitors)
- Analysis of Variance
- Animals
- Convulsants
- Diazepam
(antagonists & inhibitors, pharmacology)
- Dose-Response Relationship, Drug
- Flumazenil
(pharmacology)
- GABA Modulators
(antagonists & inhibitors, pharmacology)
- Ginsenosides
- Male
- Mice
- Morphine
(antagonists & inhibitors)
- Pain Measurement
(drug effects)
- Picrotoxin
- Pyrrolidines
(antagonists & inhibitors)
- Saponins
(antagonists & inhibitors, pharmacology)
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