HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The possible involvement of GABAA systems in the antinarcotic effect of majonoside-R2, a major constituent of Vietnamese ginseng, in mice.

Abstract
The effect of majonoside-R2 on morphine- and U-50,488H-induced antinociception was examined by the tail-pinch test in mice and compared with that of diazepam. Majonoside-R2 and diazepam inhibited the morphine- and U-50,488H-induced antinociception, and the actions were antagonized by the benzodiazepine receptor antagonist flumazenil and the GABA-gated CI- channel blocker picrotoxin. Diazepam but not majonoside-R2 exhibited a protective activity against convulsion caused by the GABAA antagonists bicuculline and picrotoxin. These results indicate that GABAA systems are involved in the effect of majonoside-R2 on the opioid-induced antinociception and suggest that the mechanisms of action of majonoside-R2 may differ from those of diazepam.
AuthorsT T Nguyen, K Matsumoto, K Yamasaki, M D Nguyen, T N Nguyen, H Watanabe
JournalJapanese journal of pharmacology (Jpn J Pharmacol) Vol. 71 Issue 4 Pg. 345-9 (Aug 1996) ISSN: 0021-5198 [Print] Japan
PMID8886934 (Publication Type: Journal Article)
Chemical References
  • Analgesics
  • Analgesics, Opioid
  • Convulsants
  • GABA Modulators
  • Ginsenosides
  • Pyrrolidines
  • Saponins
  • Picrotoxin
  • Flumazenil
  • 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
  • Morphine
  • majonoside R2
  • Diazepam
Topics
  • 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
  • Analgesics (antagonists & inhibitors)
  • Analgesics, Opioid (antagonists & inhibitors)
  • Analysis of Variance
  • Animals
  • Convulsants
  • Diazepam (antagonists & inhibitors, pharmacology)
  • Dose-Response Relationship, Drug
  • Flumazenil (pharmacology)
  • GABA Modulators (antagonists & inhibitors, pharmacology)
  • Ginsenosides
  • Male
  • Mice
  • Morphine (antagonists & inhibitors)
  • Pain Measurement (drug effects)
  • Picrotoxin
  • Pyrrolidines (antagonists & inhibitors)
  • Saponins (antagonists & inhibitors, pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: