A benfotiamine-vitamin B combination in treatment of diabetic polyneuropathy.

Abstract

In a double-blind, randomized, controlled study, the effectiveness of treatment with a combination of Benfotiamine (an Allithiamine, a lipid-soluble derivative of vitamin B1 with high bioavailability) plus vitamin B6/B12 on objective parameters of neuropathy was studied over a period of 12 weeks on 24 diabetic patients with diabetic polyneuropathy. The results showed a significant improvement (p = 0.006) of nerve conduction velocity in the peroneal nerve and a statistical trend toward improvement of the vibration perception threshold. Long-term observation of 9 patients with verum over a period of 9 months support the results. Therapy-specific adverse effects were not seen. The results of this double-blind investigation, of the long-term observation and of the reports in the literature support the contention that the neurotropic benfotiamine-vitamin B combination represents a starting point in the treatment of diabetic polyneuropathy.

• Authors: H Stracke, A Lindemann, K Federlin
• Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association (Exp Clin Endocrinol Diabetes) Vol. 104 Issue 4 Pg. 311-6 ( 1996) ISSN: 0947-7349 [Print] Germany
• PMID: 8886748 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Capsules
• Drug Combinations
• Glycated Hemoglobin A
• Pyridoxine
• Vitamin B 12
• Thiamine
• benphothiamine

Topics

• Administration, Oral
• Aged
• Capsules
• Diabetic Neuropathies (drug therapy, physiopathology)
• Double-Blind Method
• Drug Combinations
• Female
• Glycated Hemoglobin (drug effects, metabolism)
• Humans
• Male
• Median Nerve (physiology)
• Middle Aged
• Neural Conduction (drug effects, physiology)
• Perception (drug effects, physiology)
• Peroneal Nerve (physiology)
• Pyridoxine (administration & dosage, pharmacology, therapeutic use)
• Sensory Thresholds (drug effects, physiology)
• Thiamine (administration & dosage, analogs & derivatives, pharmacology, therapeutic use)
• Time Factors
• Vibration
• Vitamin B 12 (administration & dosage, pharmacology, therapeutic use)