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Postbinding functions of CD4 in HIV infection.

Abstract
Several studies have suggested that the CD4 molecule, in addition to serving as the HIV receptor, may also be involved in postbinding events of HIV infection. The CD4 molecule has been shown to assume an altered conformation on the T-cell surface following HIV binding, which may be involved in these postbinding events.
AuthorsR E Bachelder, N L Letvin
JournalTrends in microbiology (Trends Microbiol) Vol. 4 Issue 9 Pg. 359-63 (Sep 1996) ISSN: 0966-842X [Print] England
PMID8885171 (Publication Type: Journal Article, Review)
Chemical References
  • CD4 Antigens
Topics
  • CD4 Antigens (chemistry, metabolism)
  • HIV (growth & development)
  • HIV Infections
  • Humans
  • Models, Biological
  • Protein Conformation
  • Signal Transduction
  • T-Lymphocytes (chemistry, metabolism)

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