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Distribution of HHV-6 variants in human tissues.

Abstract
Human herpesvirus (HHV)-6 strains segregate into two variants (HHV-6A and HHV-6B), closely related to each other but clearly and easily distinguishable. These two HHV-6 variants differ in their ability to grow in T-cell lines, have distinctive patterns of DNA restriction fragments, and show specific reactivities with some monoclonal antibodies. The degree of DNA homology between variants ranges from 97% in the most conserved region to 75% in the immediate early region 1. HHV-6B is the etiologic agent of exanthema subitum but HHV-6A has not yet been clearly associated with any human pathology. HHV-6 sequences are frequently detected by the polymerase chain reaction (PCR) in healthy and pathological tissues. HHV-6B is more prevalent in peripheral blood mononuclear cells and in lymphatic tissue. The prevalence of HHV-6A may be greater in some pathological conditions such as Kaposi's sarcoma, and in skin biopsies. Results so far available support the hypothesis that HHV-6 variants may have different epidemiologies.
AuthorsD Di Luca, P Mirandola, T Ravaioli, B Bigoni, E Cassai
JournalInfectious agents and disease (Infect Agents Dis) Vol. 5 Issue 4 Pg. 203-14 (Oct 1996) ISSN: 1056-2044 [Print] United States
PMID8884365 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Topics
  • Exanthema Subitum (epidemiology)
  • Herpesvirus 6, Human (classification, immunology, pathogenicity)
  • Humans
  • Molecular Epidemiology

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