Besipirdine (HP 749) reduces schedule-induced polydipsia in rats.

Abstract	The aim of the present paper is to report on the adrenergic and serotonergic effects of besipirdine (HP 749) in vivo and to discuss its potential use in the treatment of obsessive compulsive disorder. Besipirdine inhibited biogenic amine uptake in vitro. It prevented tetrabenazine-induced ptosis in mice and potentiated the 5-hydroxytryptophan-induced serotonin syndrome in rats. Furthermore, it decreased schedule-induced polydipsic behavior in rats. Schedule-induced polydipsia may be a model for obsessive compulsive disorder. Previous results from our group have shown that certain selective serotonin reuptake inhibitors decrease schedule-induced polydipsia after 14-21 days of treatment. Besipirdine reduced schedule-induced polydipsic behavior immediately and this reduction lasted throughout the duration of the experiment (29 days).
Authors	A T Woods-Kettelberger, C P Smith, R Corbett, M R Szewczak, J E Roehr, G M Bores, J T Klein, S Kongsamut
Journal	Brain research bulletin (Brain Res Bull) Vol. 41 Issue 2 Pg. 125-30 ( 1996) ISSN: 0361-9230 [Print] United States
PMID	8879677 (Publication Type: Journal Article)
Chemical References	Biogenic Amines Indoles Neurotransmitter Uptake Inhibitors Pyridines Receptors, Serotonin Serotonin Receptor Agonists Serotonin Uptake Inhibitors Sympatholytics Fluoxetine 8-Hydroxy-2-(di-n-propylamino)tetralin besipirdine Desipramine
Topics	8-Hydroxy-2-(di-n-propylamino)tetralin (pharmacology) Animals Biogenic Amines (metabolism) Blepharoptosis (chemically induced, prevention & control) Conditioning, Operant (drug effects) Desipramine (pharmacology) Drinking Behavior (drug effects) Female Fluoxetine (pharmacology) Hippocampus (metabolism) In Vitro Techniques Indoles (pharmacokinetics, pharmacology) Male Mice Neurotransmitter Uptake Inhibitors (pharmacology) Pyridines (pharmacokinetics, pharmacology) Rats Rats, Wistar Receptors, Serotonin (drug effects, metabolism) Reinforcement Schedule Serotonin Receptor Agonists (pharmacology) Selective Serotonin Reuptake Inhibitors (pharmacology) Sympatholytics (pharmacokinetics, pharmacology) Synaptosomes (metabolism)

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