This study examined the effects of administering 0.5, 4, 10, and 30 mL/kg of
Diaspirin Crosslinked
Hemoglobin (
DCLHb) in a swine model of non-lethal
hemorrhagic shock. Thirty unanesthetized animals were bled (30 mL/kg, 1 mL/kg/min) and either recovered without treatment (Untreated Control, UC) or infused with 10 g/dL
DCLHb (0.5, 4.0, 10 or 30 mL/kg at 1 mL/kg/min) or Lactated Ringer (LR, 90 mL/kg at 3 mL/kg/min).
DCLHb caused dose-related increases in MAP. Both the 10 and 30 mL/kg doses of
DCLHb increased MAP more than UC or LR. Lower doses of
DCLHb and LR had effects on MAP similar to UC. After
hemorrhage, CO increased in all groups. The effect of
DCLHb on CO was dose-related. Only LR and 30 mL/kg of
DCLHb transiently (through 90 min) increased CO more than UC. CO in animals given lower doses of
DCLHb was comparable to UC.
DCLHb (10 and 30 mL/kg) improved base excess and
lactate concentrations, two indices of global perfusion, more rapidly and to a greater extent than either UC or LR. In this swine model of
hemorrhage, even small doses of
DCLHb exerted measurable beneficial effects on blood pressure and perfusion.