The effectiveness of two ciprofloxacin formulations for experimental Pseudomonas and Staphylococcus keratitis.

Abstract	Ciprofloxacin is a fluoroquinolone antibiotic with broad spectrum bactericidal activity. A commercially available form of ciprofloxacin contains benzalkonium chloride (BAC) (0.006%) and EDTA (0.05%) as preservatives. Since BAC has been shown to cause adverse changes in corneal epithelial cells, a formulation of ciprofloxacin devoid of BAC and EDTA but with the same effectiveness would be valuable. We present here the results of experiments designed to assess the efficacy of a BAC-free and EDTA-free formulation of ciprofloxacin, Ciprofloxacin-polystyrene sulfonate (PSS), in experimental models of Pseudomonas aeruginosa and Staphylococcus aureus keratitis. Both formulations of ciprofloxacin sterilized corneas infected with P aeruginosa, and both formulations showed equal bactericidal activity for S aureus. Normal eyes treated with either formulation showed mild conjunctival irritation compared to untreated normal eyes. The bactericidal activities of both formulations of ciprofloxacin were excellent. Therefore, the Ciprofloxacin-PSS formulation could serve as an effective single drug therapy for ocular infections.
Authors	L S Engel, M C Callegan, J M Hill, A T Folkens, Y Shimomura, R J O'Callaghan
Journal	Japanese journal of ophthalmology (Jpn J Ophthalmol) Vol. 40 Issue 2 Pg. 212-9 ( 1996) ISSN: 0021-5155 [Print] Japan
PMID	8876389 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Anti-Infective Agents Benzalkonium Compounds Chelating Agents Ophthalmic Solutions Preservatives, Pharmaceutical Ciprofloxacin Edetic Acid
Topics	Animals Anti-Infective Agents (pharmacology) Benzalkonium Compounds Chelating Agents Ciprofloxacin (pharmacology) Colony Count, Microbial Cornea (drug effects, microbiology) Disease Models, Animal Edetic Acid Eye Infections, Bacterial (drug therapy) Keratitis (drug therapy, microbiology) Ophthalmic Solutions Preservatives, Pharmaceutical Pseudomonas Infections (drug therapy) Pseudomonas aeruginosa (drug effects, isolation & purification) Rabbits Staphylococcal Infections (drug therapy) Staphylococcus aureus (drug effects, isolation & purification)

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