Decreased serum 1,5-anhydroglucitol in nondiabetic subjects with a family history of NIDDM.

Abstract

OBJECTIVE:

To investigate the effect of a family history of NIDDM on HbAlc and serum 1,5-anhydroglucitol (AG) in nondiabetic subjects.

RESEARCH DESIGN AND METHODS:

A 75-g oral glucose tolerance test was performed; 258 subjects with normal glucose tolerance and 106 subjects with impaired glucose tolerance (IGT) were selected HbAlc and serum AG were compared between subjects with and without a family history of NIDDM. The relationships between age, BMI, HbAlc, serum AG, fasting and 2-h plasma glucose, and urinary glucose were also examined using principal component analysis with a varimax rotation.

RESULTS:

In the normal group, only serum AG was lower in subjects with a positive family history than in those with no family history. On the other hand, in the IGT group, subjects with a positive family history were younger and had a higher 2-h plasma glucose, a higher urinary glucose, and a lower serum AG than those with no family history, whereas there was no difference in HbAlc. Principal component analysis identified three factors. The first factor, a linear combination of HbAlc and fasting plasma glucose, was labeled an average glycemic factor. The second factor, which included serum AG, 2-h plasma glucose, and urinary glucose, was labeled an oscillatory glycemic factor. The third factor, which contrasted age against BMI, was labeled an environmental factor.

CONCLUSIONS:

Serum AG is related to glycosuria even among nondiabetic subjects, and its concentrations are decreased in those with a family history of NIDDM. Our results suggest that serum AG rather than HbAlc reflects early metabolic abnormalities in these subjects.

• Authors: S Tsukui, Y Fukumura, I Kobayashi
• Journal: Diabetes care (Diabetes Care) Vol. 19 Issue 9 Pg. 940-4 (Sep 1996) ISSN: 0149-5992 [Print] United States
• PMID: 8875086 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Blood Glucose
• Glycated Hemoglobin A
• 1,5-anhydroglucitol
• Deoxyglucose

Topics

• Analysis of Variance
• Biomarkers (blood)
• Blood Glucose (metabolism)
• Deoxyglucose (blood)
• Diabetes Mellitus, Type 2 (genetics)
• Glucose Intolerance (blood)
• Glucose Tolerance Test
• Glycated Hemoglobin (analysis)
• Glycosuria
• Humans
• Isomerism
• Middle Aged
• Nuclear Family
• Reference Values