HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Inhibition of experimental metastasis by enzyme inhibitors from microorganisms and plants.

Abstract
Various antibacterial compounds, antitumor compounds, enzyme inhibitors and recent signal transduction inhibitors have been discovered from microorganisms and plants. Therefore, it should be possible to find antimetastatic compounds from these sources, if a simple assay system is available. We isolated several enzyme inhibitors from nature to inhibit experimental metastasis. Leupeptin is an old protease inhibitor and inhibited blood-borne lung metastasis of hepatoma cells in rats. A leupeptin analogue inhibiting urokinase inhibited in vitro invasion of human fibrosarcoma cells. Alpha-glucosidase inhibitors such as epi-CPL and baicalein inhibited in vitro invasion and in vivo metastasis of mouse melanoma cells. A mannosidase inhibitor, mannostatin A, also inhibited in vitro invasion of mouse melanoma cells. Oncogene function inhibitors induce normal phenotypes in the oncogene-expressing cells. As expected, they inhibited tumor cell invasion in vitro.
AuthorsK Umezawa
JournalAdvances in enzyme regulation (Adv Enzyme Regul) Vol. 36 Pg. 267-81 ( 1996) ISSN: 0065-2571 [Print] England
PMID8869751 (Publication Type: Journal Article, Review)
Chemical References
  • Enzyme Inhibitors
  • Leupeptins
  • Matrix Metalloproteinase Inhibitors
  • Protease Inhibitors
  • Glycoside Hydrolases
  • Collagenases
Topics
  • Animals
  • Carcinoma, Hepatocellular (enzymology, metabolism)
  • Collagenases (metabolism)
  • Enzyme Inhibitors (pharmacology)
  • Glycoside Hydrolases (antagonists & inhibitors)
  • Leupeptins (pharmacology)
  • Lung (enzymology, metabolism)
  • Matrix Metalloproteinase Inhibitors
  • Mice
  • Neoplasm Metastasis
  • Neoplasms, Experimental (enzymology, metabolism)
  • Protease Inhibitors (pharmacology)
  • Rats

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: