The effect of anti-
cancer drugs on the metabolic efficiency of the liver was evaluated by means of
phenazone (
antipyrine) kinetics individually in each rat.
Chlormethine (
nitrogranulogen, NG),
methotrexate (MTX),
floxuridine (fluorouracil, 5-fluorouracil, 5-FU),
cyclophosphamide (CY,
endoxan), and three
cytostatics applied jointly (MTX + 5-FU + CY) were administered ip to the rats, while
antipyrine was given intravenously. The anti-
cancer drugs: NG, MTX,
5-FU, CY and MTX +
5-FU + CY delayed the elimination of
antipyrine. Statistically significant prolongation of the half-life, decrease in the elimination rate constant and the clearance of
antipyrine have been found in the rats receiving anti-
cancer drugs, as compared to the controls. After the administration of MTX,
5-FU, CY and the joint administration of MTX +
5-FU + CY the volume of distribution did not change, while the volume of distribution of
antipyrine decreased after the administration of NG. The activity of the investigated
enzymes, i.e.,
alanine aminotransferase (ALAT), aspartic
aminotransferase (AspAT),
gamma-glutamyltransferase (GGT),
alkaline phosphatase (AP), which are the indicators of various
liver dysfunctions, did not change after the administration of NG, MTX,
5-FU, CY and MTX +
5-FU + CY. The administered
antineoplastic drugs in mono and polytherapy changed the activity of
oxidase mixed function responsible for the metabolism of
antipyrine. CY administered to rats in polytherapy had less influence on liver metabolic efficiency than in monotherapy.