Abstract |
A novel, computer-driven, dynamic-force detector was validated for use in measuring the formalin-induced agitation response. Intraplantar administration of formalin (0.25-5%) provoked a biphasic agitation response as measured with the automated system. The magnitude of both phases of the response increased with the intensity of the noxious stimulus. Morphine (1-5 mg/kg, s.c.) inhibited both phase 1 and 2 of the agitation response evoked by 5% formalin with ID50 values of 2.07 +/- 0.47 and 1.35 +/- 0.02 mg/kg, respectively. The non- peptide, NK1 antagonist, (+/-)- CP-96,345 (30 mg/kg, s.c.), partially blocked phase 2 but did not alter the magnitude of phase 1. These results are comparable with those obtained by us and others using a multiple- pain-behavior scoring system or certain uni-dimensional measures. In addition, they indicate that the automated system yields a valid measure of the formalin-induced agitation response.
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Authors | M F Jett, S Michelson |
Journal | Pain
(Pain)
Vol. 64
Issue 1
Pg. 19-25
(Jan 1996)
ISSN: 0304-3959 [Print] United States |
PMID | 8867244
(Publication Type: Journal Article)
|
Chemical References |
- Biphenyl Compounds
- Formaldehyde
- Morphine
- CP 96345
|
Topics |
- Animals
- Behavior, Animal
(drug effects)
- Biphenyl Compounds
(pharmacology)
- Dose-Response Relationship, Drug
- Evaluation Studies as Topic
- Foot
- Formaldehyde
- Male
- Morphine
(pharmacology)
- Pain
(chemically induced, physiopathology)
- Pain Measurement
(methods)
- Rats
- Rats, Sprague-Dawley
- Signal Processing, Computer-Assisted
- Stimulation, Chemical
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