Abstract | BACKGROUND: METHODS: This review is based on own experiments considered against literature data. RESULTS AND CONCLUSIONS: Brain detoxifies ammonia during liver failure by ammonia uptake from the blood, glutamine synthesis and subsequent glutamine release into the blood. Although quantitatively unimportant, this may be qualitatively important, because it may influence metabolic and/or neurotransmitter glutamate concentrations. The kidney plays an important role in adaptation to hyperammonaemia by reversing the ratio of ammonia excreted in the urine versus ammonia released into the blood from 0.5 to 2. Thus, the kidney changes into an organ that netto removes ammonia from the body as opposed to the normal situation in which it adds ammonia to the body pools.
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Authors | C H Dejong, N E Deutz, P B Soeters |
Journal | Scandinavian journal of gastroenterology. Supplement
(Scand J Gastroenterol Suppl)
Vol. 218
Pg. 61-77
( 1996)
ISSN: 0085-5928 [Print] England |
PMID | 8865453
(Publication Type: Journal Article, Review)
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Chemical References |
- Glutamine
- Ammonia
- Nitrogen
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Topics |
- Ammonia
(metabolism)
- Animals
- Brain
(metabolism)
- Glutamine
(metabolism)
- Humans
- Kidney
(metabolism)
- Liver Failure, Acute
(metabolism, physiopathology)
- Nitrogen
(metabolism, pharmacokinetics)
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