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Peripapillary fluorescein leakage in 11778 Leber's optic neuropathy.

Abstract
A 17-year-old young man presented with a 2-month sequential visual loss in both eyes. Vision was 20/200 in the right eye and 20/400 in the left eye. Both discs were hyperemic with circumpapillary telangiectasia and nerve fiber swelling. Fluorescein angiography revealed a fuzzy hyperfluorescence due to leakage from dilated capillaries on both discs in the late transit. Molecular mitochondrial DNA study confirmed a homoplasmic 11778 Leber's optic neuropathy.
AuthorsM Y Yen, Y H Wei, J H Liu
JournalJournal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society (J Neuroophthalmol) Vol. 16 Issue 3 Pg. 178-81 (Sep 1996) ISSN: 1070-8022 [Print] United States
PMID8865009 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • DNA, Mitochondrial
  • Fluoresceins
  • Fluorescein
Topics
  • Adolescent
  • Adult
  • Capillary Permeability
  • DNA, Mitochondrial (genetics)
  • Female
  • Fluorescein
  • Fluorescein Angiography
  • Fluoresceins (metabolism)
  • Fundus Oculi
  • Humans
  • Male
  • Optic Atrophies, Hereditary (diagnosis, genetics, physiopathology)
  • Optic Disk (blood supply)
  • Optic Nerve (pathology)
  • Point Mutation
  • Retinal Vessels (metabolism, pathology)
  • Telangiectasis (pathology)
  • Visual Acuity

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