Livedo reticularis and thrombotic purpura related to the use of diphenhydramine associated with pyrithyldione.

Abstract	We describe the case of a young woman who habitually took large doses of a combination of diphenhydramine and pyrithyldione. She complained of arthralgia, painful recurring plaques and nodules, together with persistent reticular purpuric mottling and areas of necrosis on her legs. There were positive antinuclear antibodies and rheumatoid factor and histologically massive thrombosis of the dermal vessels without signs of vasculitis. Other cases of similar adverse reactions attributed to this drug combination used as a hypnotic have been described.
Authors	A Morell, R Botella, J F Silvestre, I Betlloch, M R Alfonso, M D Ruiz
Journal	Dermatology (Basel, Switzerland) (Dermatology) Vol. 193 Issue 1 Pg. 50-1 ( 1996) ISSN: 1018-8665 [Print] Switzerland
PMID	8864620 (Publication Type: Case Reports, Journal Article)
Chemical References	Drug Combinations Hypnotics and Sedatives Pyridones pyrithyldione Diphenhydramine
Topics	Adult Arthralgia (chemically induced, pathology) Diphenhydramine (adverse effects) Drug Combinations Drug Interactions Female Humans Hypnotics and Sedatives (adverse effects) Purpura, Thrombocytopenic (chemically induced, complications) Pyridones (adverse effects) Remission, Spontaneous Skin Diseases, Vascular (chemically induced, complications)

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