[Plasma renin activity in tachistin-stimulated hypercalcemia and under the effect of chlorazine].
|
| Abstract |
The aim of the present study was to elucidate the correlation between the Renin secretion and increased Plasma Calcium concentration and the role of Calmodulin in this process. Plasma Renin activity was determined radioimmunologically in 31 white rats, that were grouped as follows: group I - 7 controls loaded for 6 days perorally with 0.5 ml/200 g b.w. glycerin and injected i.m. for 6 days with 0.1 ml/200 g b.w. with 0.9% NaCl; group II - 8 rats, treated for 6 days with Tachistin 0.0025 mg/200 g b.w., dissolved in glycerin 0.5 ml/200 g b.w.; group III - 5 rats, treated with Tachistin 0.005 mg/200 g b.w. in the same manner; group IV - 5 rats injected i.m. with Chlorazin 0.5 mg/200 g b.w. for 6 days; group V - 6 rats, loaded with double dose Tachistin and with Chlorazin 0.5 mg/200 g b.w. for 6 days. Blood samples were taken intracardially on the seventh day from the beginning of the experiment and were analyzed with kits of Sorin-Biomedica-Italy. Our results suggest that the hypercalcemia induced by Tachistin caused a dose-dependent increase of PRA and Ca-Calmodulin complex is the dominant second messenger of Renin secretion.
|
|---|---|
| Authors | G Ilieva, A Tolekova, A Logofetov, K Trifonova |
| Journal | Eksperimentalna meditsina i morfologiia (Eksp Med Morfol) Vol. 32 Issue 3-4 Pg. 1-8 ( 1994) ISSN: 0367-0643 [Print] Bulgaria |
| Vernacular Title | Plazmena reninova aktivnost pri stimulirana chrez takhistin khiperkaltsiemiia i pri prilozhenie na khlorazin. |
| PMID | 8857027 (Publication Type: Comparative Study, English Abstract, Journal Article) |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!