Abstract |
We studied the effect of two new class II antiarrhythmics, ambasilide and dofetilide, on the action potential duration (APD) of guinea pig right ventricular papillary muscle at different extracellular potassium concentrations ([K+e]) and pacing frequencies. Under normal [K+e], both drugs significantly prolonged APD90 (APD at 90% repolarization) at 0.5 Hz. The effect of ambasilide was well preserved at rapid pacing rates, independent of [K+e]. The effect of dofetilide was markedly reduced with increasing pacing rate, especially in high [K+e]. Therefore, ambasilide may be useful in treating tachyarrhythmias in normal, as well as in altered [K+e] conditions.
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Authors | V Gjini, M Korth, J Schreieck, S Weyerbrock, A Schömig, C Schmitt |
Journal | Journal of cardiovascular pharmacology
(J Cardiovasc Pharmacol)
Vol. 28
Issue 2
Pg. 314-20
(Aug 1996)
ISSN: 0160-2446 [Print] United States |
PMID | 8856489
(Publication Type: Journal Article)
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Chemical References |
- Aminobenzoates
- Anti-Arrhythmia Agents
- Bridged Bicyclo Compounds, Heterocyclic
- Phenethylamines
- Sulfonamides
- ambasilide
- dofetilide
- Potassium
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Topics |
- Action Potentials
(drug effects)
- Aminobenzoates
(pharmacology)
- Animals
- Anti-Arrhythmia Agents
(pharmacology)
- Bridged Bicyclo Compounds, Heterocyclic
(pharmacology)
- Cardiac Pacing, Artificial
- Extracellular Space
(drug effects, physiology)
- Female
- Guinea Pigs
- Heart
(drug effects)
- Heart Rate
(drug effects, physiology)
- In Vitro Techniques
- Male
- Membrane Potentials
(drug effects, physiology)
- Phenethylamines
(pharmacology)
- Potassium
(physiology)
- Sulfonamides
(pharmacology)
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