Abstract | BACKGROUND: METHODS: From February 1994 to April 1994, in total 25 men with symptomatic benign prostatic hyperplasia were enrolled into this prospective study. All patients were treated with finasteride 5 mg per day for six months. RESULTS: Seven patients withdrew from the study, one for exasperated symptoms, three for personal reasons and three patients were excluded because of poor compliance. In total 18 patients completed the six-month therapy and surveillance. The AUA symptom scores improved on average by 6.3 points; prostatic adenoma volume reduced from baseline by 17%, and the serum prostate specific antigen (PSA) level decreased by 35%. No improvement of the rate of urinary flow was noted. Sixty-one per cent of patients had more than 50% improvement in subjective symptom scores, 28 per cent of men showed per cent or greater decrease in prostate volume. However, only one patient showed an increase of 3 mL/s or more in maximal flow rate at the end of study. Six patients reported adverse sexual experiences ( impotence in 3, decreased rigidity in 1, and decreased libido in 2) and one had GI upset. CONCLUSIONS: A subset of patients with benign prostatic hyperplasia may benefit from treatment with finasteride. Although most patients experienced subjective improvement, increase in maximal flow rate is unsatisfactory in this preliminary report.
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Authors | T T Wu, Y H Lee, B P Jiaan, J K Huang |
Journal | Zhonghua yi xue za zhi = Chinese medical journal; Free China ed
(Zhonghua Yi Xue Za Zhi (Taipei))
Vol. 56
Issue 6
Pg. 399-403
(Dec 1995)
ISSN: 0578-1337 [Print] China (Republic : 1949- ) |
PMID | 8851481
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- 5-alpha Reductase Inhibitors
- Enzyme Inhibitors
- Finasteride
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Topics |
- 5-alpha Reductase Inhibitors
- Aged
- Aged, 80 and over
- Enzyme Inhibitors
(therapeutic use)
- Finasteride
(therapeutic use)
- Humans
- Male
- Middle Aged
- Prospective Studies
- Prostatic Hyperplasia
(drug therapy)
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