HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Combined chemotherapy with 5-FU and low dose CDDP for advanced or recurrent cancer of the digestive system and home anti-cancer chemotherapy].

Abstract
We have performed combined chemotherapy with 5-FU, a biochemical modulator, and low dose CDDP for advanced or recurrent cancer of the digestive system. The therapy was effective in 37% of all cases and in 45.5% and 41.6% of esophageal and gastric cancer cases, respectively. In addition, few patients developed adverse side effects including renal disorders, one of the major side effects of CDDP. Therefore, we considered home anti-cancer chemotherapy feasible. For 27 outpatients with advanced cancer of the digestive system including 15 cases of esophageal cancer, 4 cases of gastric cancer, 3 cases of colon cancer, 4 cases of pancreatic cancer and 1 case of gall bladder cancer, 4 to 6 week home adjuvant chemotherapy was performed. The regimen comprised 1 week of oral administration of 300 mg/body/day of UFT-E granules and 5 days of continuous intravenous infusion of 25 mg/body/day of CDDP using an infusor pump. During the follow-up, 3 cases of catheter obstruction, 3 cases of catheter sepsis and 1 case of pneumothorax appeared. These complications all resulted from the catheter, and safe home anti-cancer chemotherapy could be continued because 5-FU and CDDP did not cause severe side effects.
AuthorsT Ogura, Y Hiramatsu, H Araki, Y Kojima, A Nakagawa, M Nakagawa, Y Kamiyama, T Shirasaka
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 22 Suppl 4 Pg. 433-8 (Dec 1995) ISSN: 0385-0684 [Print] Japan
PMID8849289 (Publication Type: Clinical Trial, English Abstract, Journal Article)
Chemical References
  • Tegafur
  • Uracil
  • Cisplatin
  • Fluorouracil
Topics
  • Administration, Oral
  • Ambulatory Care
  • Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
  • Chemotherapy, Adjuvant
  • Cisplatin (administration & dosage, adverse effects)
  • Digestive System Neoplasms (drug therapy)
  • Drug Administration Schedule
  • Female
  • Fluorouracil (administration & dosage, adverse effects)
  • Home Care Services, Hospital-Based
  • Humans
  • Infusion Pumps
  • Infusions, Intravenous
  • Male
  • Neoplasm Recurrence, Local (drug therapy)
  • Quality of Life
  • Tegafur (administration & dosage)
  • Uracil (administration & dosage)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: