Abstract |
Anti-invasive and anti-metastatic effects of anti- integrin antibodies (against VLA-alpha 2, alpha 4, beta 1) were examined on human fibrosarcoma cells using in vitro invasion assay in a reconstituted basement membrane ( Matrigel) and experimental metastatic assay in a chick embryo. The effects of anti- integrin antibodies were compared with those of RGD-containing peptides ( GRGDS), which have been known as effective inhibitors of tumor cell metastasis. Although slight differences in effective concentration among antibodies were observed, invasion and metastasis were significantly inhibited by anti- integrin antibodies. The results also showed partial inhibitory effect of GRGDS on the invasion and metastasis of human fibrosarcoma cells. These results indicate that integrin receptors mediating cell-cell/cell-extracellular matrix components interactions play a key role in the invasion and metastasis of human fibrosarcoma cells.
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Authors | R H Park, I Yun |
Journal | Cancer letters
(Cancer Lett)
Vol. 106
Issue 2
Pg. 227-33
(Sep 10 1996)
ISSN: 0304-3835 [Print] Ireland |
PMID | 8844977
(Publication Type: Journal Article)
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Chemical References |
- Oligopeptides
- Receptors, Very Late Antigen
- arginyl-glycyl-aspartic acid
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Topics |
- Animals
- Chick Embryo
- Fibrosarcoma
(pathology, secondary)
- Humans
- Neoplasm Invasiveness
- Oligopeptides
(physiology)
- Receptors, Very Late Antigen
(physiology)
- Tumor Cells, Cultured
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