The effect of SM-8849 on experimental arthritis in mice.

Abstract	The effect of a novel thiazole derivative, SM-8849, on experimental arthritis in mice was studied and compared to that of prednisolone. SM-8849 and prednisolone reduced the incidence and severity of type II collagen-induced arthritis in mice, as assayed by clinical observation and histopathological studies. Although both agents inhibited type II collagen-induced delayed type hypersensitivity (DTH) in arthritic mice, SM-8849 did not affect the production of humoral antibodies to type II collagen. To examine the inhibitory mechanism of SM-8849, the effects on T cell-dependent allergic inflammation were studied. SM-8849 clearly inhibited T cell-dependent reactions including staphylococcal enterotoxin B (SEB)-induced arthritis, SEB-induced CD25 expression on T cells and sheep red blood cell (SRBC)-induced DTH reaction. SM-8849, however, had no effect on the production of humoral antibody forming cells in the spleen of mice immunized with SRBC. These results indicate that inhibition of type II collagen-induced arthritis by SM-8849 is mainly due to the inactivation of T cells that are related to DTH reaction.
Authors	H Nagai, Y Takaoka, K Kuwabara, H Kamada, K Kitagaki
Journal	Pharmacology (Pharmacology) Vol. 52 Issue 6 Pg. 377-86 (Jun 1996) ISSN: 0031-7012 [Print] Switzerland
PMID	8844788 (Publication Type: Comparative Study, Journal Article)
Chemical References	Adjuvants, Immunologic Biphenyl Compounds CD4 Antigens Enterotoxins Receptors, Interleukin-2 Superantigens Thiazoles 4-(1-(2-fluoro-4-biphenyl)ethyl)-2-methylaminothiazole enterotoxin B, staphylococcal Collagen Prednisolone
Topics	Adjuvants, Immunologic (pharmacology) Animals Antibody Formation Antibody-Producing Cells (immunology) Arthritis (drug therapy, immunology, pathology) Biphenyl Compounds (pharmacology) CD4 Antigens (immunology) Cattle Collagen (immunology) Disease Models, Animal Enterotoxins (immunology) Hypersensitivity, Delayed Immunity, Cellular Immunization Male Mice Mice, Inbred DBA Prednisolone (pharmacology) Receptors, Interleukin-2 (immunology) Superantigens (immunology) T-Lymphocytes (drug effects, immunology) Thiazoles (pharmacology)

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