Protective effects of BQ-123, an ETA receptor antagonist, against leukotoxin-induced injury in rat lungs.

Abstract

We tested the hypothesis that BQ-123, a novel endothelin type A (ETA) receptor antagonist, protects the lung against leukotoxin 9,10-epoxy-12-octadecenoate (Lx), which causes acute lung injury in animals. In isolated rat lungs perfused with Earle's balanced salt solution, BQ-123 suppressed the Lx-induced increase in wet lung weight, wet lung weight/dry lung weight, the effluent perfusate lactic dehydrogenase activity, and effluent perfusate and lung tissue ET-1 levels. BQ-123 also significantly attenuated the Lx-induced increase of the pulmonary capillary filtration coefficient. Thus our experimental results indicate that the ETA receptor antagonist, BQ-123, protects against Lx-induced experimental lung vascular injury.

• Authors: T Ishizaki, K Shigemori, S Ameshima, T Nakai, S Miyabo, M Hayakawa, T Ozawa, N F Voelkel
• Journal: The American journal of physiology (Am J Physiol) Vol. 271 Issue 3 Pt 1 Pg. L459-63 (Sep 1996) ISSN: 0002-9513 [Print] United States
• PMID: 8843795 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Endothelin Receptor Antagonists
• Exotoxins
• Immunosuppressive Agents
• Peptides, Cyclic
• leukotoxin
• cyclo(Trp-Asp-Pro-Val-Leu)

Topics

• Animals
• Endothelin Receptor Antagonists
• Exotoxins (toxicity)
• Immunosuppressive Agents (toxicity)
• Lung (drug effects, pathology)
• Male
• Peptides, Cyclic (administration & dosage)
• Pulmonary Edema (chemically induced, prevention & control)
• Rats
• Rats, Sprague-Dawley