Dissociation of body-temperature and melatonin secretion circadian rhythms in patients with chronic fatigue syndrome.

Many patients with chronic fatigue syndrome (CFS) display features of hypothalamic dysfunction. We have investigated aspects of circadian rhythmicity, an important hypothalamic function, in 20 CFS patients and in 17 age- and sex-matched healthy control subjects. There were no differences between the two groups in the amplitude, mesor (mean value) or timing of the peak (acrophase) of the circadian rhythm of core temperature, or in the timing of the onset of melatonin secretion. However, the CFS patients showed no significant correlation between the timing of the temperature acrophase and the melatonin onset (P < 0.5), whereas the normal significant correlation was observed in the controls (P < 0.05). Dissociation of circadian rhythms could be due to the sleep deprivation and social disruption, and/or the reduction in physical activity which typically accompany CFS. By analogy with jet-lag and shift-working, circadian dysrhythmia could be an important factor in initiating and perpetuating the cardinal symptoms of CFS, notably tiredness, impaired concentration and intellectual impairment.
AuthorsG Williams, J Pirmohamed, D Minors, J Waterhouse, I Buchan, J Arendt, R H Edwards
JournalClinical physiology (Oxford, England) (Clin Physiol) Vol. 16 Issue 4 Pg. 327-37 (Jul 1996) ISSN: 0144-5979 [Print] ENGLAND
PMID8842569 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Melatonin
  • Adult
  • Body Temperature (physiology)
  • Circadian Rhythm (physiology)
  • Fatigue Syndrome, Chronic (blood, physiopathology)
  • Female
  • Humans
  • Male
  • Melatonin (secretion)
  • Middle Aged
  • Radioimmunoassay
  • Retrospective Studies

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: