| Abstract | We have used serum from patients with amebic liver abscess to investigate the role of antibody in the prevention of invasive amebiasis using the severe combined immunodeficient (SCID) mouse model of Entamoeba histolytica infection. The SCID mice were passively immunized with serum or purified antibody from patients with amebic liver abscess 24 hr prior to the direct intrahepatic challenge with 10(6) virulent E. histolytica trophozoites. This treatment reduced the mean abscess size in these animals from 24.5% to 3.5% (P < 0.0001). These results demonstrate that human anti-amebic antibodies are capable of exerting a protective effect in an animal model of amebic liver abscess formation. |
| Authors | K B Seydel, K L Braun, T Zhang, T F Jackson, S L Stanley Jr
(Affiliation: Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.)
|
| Journal | The American journal of tropical medicine and hygiene
(Am J Trop Med Hyg)
Vol. 55
Issue 3
Pg. 330-2
(Sep 1996)
ISSN: 0002-9637 UNITED STATES |
| PMID | 8842124
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
|
| Chemical References |
|
| Topics |
- Animals
- Antibodies, Protozoan
(immunology)
- Entamoeba histolytica
(immunology)
- Humans
- Immunization, Passive
- Liver Abscess, Amebic
(prevention & control)
- Mice
- Mice, SCID
|
