| Abstract |
The synthesis and anti-RSV (Rouse Sarcoma Virus) activity of HMCA, (+/-)-9-(2-hydroxymethyl-cyclopenthyl)- adenine, and its derivatives are described. It has been demonstrated that trans- HMCA has greater anti-RSV activity in tissue culture than cis- HMCA. |
| Authors | E Kojima, K Ohta, S Miyawaki, T Date, M Machida, K Murakami |
| Journal | Nucleic acids symposium series
(Nucleic Acids Symp Ser)
Issue 34
Pg. 107-8
( 1995)
ISSN: 0261-3166 [Print] England |
| PMID | 8841575
(Publication Type: Journal Article)
|
| Chemical References |
|
| Topics |
- Adenine
(analogs & derivatives, chemical synthesis, pharmacology)
- Animals
- Antiviral Agents
(chemical synthesis, chemistry, pharmacology)
- Avian Sarcoma Viruses
(drug effects)
- Chick Embryo
- Drug Evaluation, Preclinical
- Fibroblasts
- HIV-1
(drug effects)
- In Vitro Techniques
- Stereoisomerism
- Structure-Activity Relationship
|
