Augmentation by phthalimides of phorbol ester-induced expression of tumor necrosis factor alpha message.

Abstract

N(alpha)-Phthalimidoglutarimide (thalidomide), 2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione (PP-33) and its 4,5,6,7-tetrafluoro derivative (FPP-33) augmented 12-O-tetradecanoylphorbol 13-acetate-induced production by human leukemia HL-60 cells of both tumor necrosis factor alpha (TNF-alpha) mRNA and secreted TNF-alpha protein. Intracellular TNF-alpha protein production was increased to a lesser extent.

• Authors: A Azuma, H Miyachi, Y Shibata, Y Hashimoto, S Iwasaki
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 19 Issue 7 Pg. 1001-3 (Jul 1996) ISSN: 0918-6158 [Print] Japan
• PMID: 8839978 (Publication Type: Journal Article)

Chemical References

• 2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione
• 2-(2,6-diisopropylphenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3-dione
• Carcinogens
• Isoindoles
• Phthalimides
• RNA, Messenger
• Tumor Necrosis Factor-alpha
• Thalidomide
• Tetradecanoylphorbol Acetate

Topics

• Blotting, Northern
• Carcinogens (toxicity)
• HL-60 Cells
• Humans
• Isoindoles
• Phthalimides (toxicity)
• RNA, Messenger (biosynthesis)
• Signal Transduction (drug effects)
• Tetradecanoylphorbol Acetate (toxicity)
• Thalidomide (toxicity)
• Tumor Necrosis Factor-alpha (biosynthesis, metabolism)