Expression of E-cadherin in skin carcinomas.

Abstract

In this study, we investigated the expression of E-cadherin in 31 cases of human skin carcinoma including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), Paget's disease, Bowen's disease (invasive type), and trichilemmal carcinoma, by immunohistochemical staining using a monoclonal antibody specific for E-cadherin. Similar to the E-cadherin expression in normal epidermis, E-cadherin was strongly expressed in all samples of BCC on the cell borders, whereas marked decrease or loss of E-cadherin expression was found in the tumor cells of SCC, Paget's disease, and Bowen's disease (invasive type). On the other hand, E-cadherin expression of trichilemmal carcinoma was slightly reduced. Considering the clinical and histological features of these skin carcinoma, the reduction of E-cadherin expression is considered to be associated with the invasion and metastasis of human skin carcinoma.

• Authors: H Tada, M Hatoko, T Muramatsu, T Shirai
• Journal: The Journal of dermatology (J Dermatol) Vol. 23 Issue 2 Pg. 104-10 (Feb 1996) ISSN: 0385-2407 [Print] England
• PMID: 8839237 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Cadherins

Topics

• Adult
• Aged
• Aged, 80 and over
• Bowen's Disease (immunology, pathology)
• Cadherins (analysis, metabolism)
• Carcinoma, Basal Cell (immunology, pathology)
• Carcinoma, Squamous Cell (immunology, pathology)
• Disease Progression
• Female
• Fluorescent Antibody Technique
• Hair (immunology, pathology)
• Humans
• Male
• Middle Aged
• Paget Disease, Extramammary (immunology, pathology)
• Sensitivity and Specificity
• Skin Neoplasms (immunology, pathology)