[Effect of semi-synthetic penicillins and cephaloridine on indices of immunologic reactivity and protein metabolism during treatment of puerperal infection].

Abstract

The effect of semisynthetic penicillins, such as methicillin and oxacillin and cephalosporins, such as cephaloridin of immunity and protein metabolism was studied on 63 patients with postnatal mastitis and endomyometritis. It was shown that the above antibiotics had no significant effect on the immunological reactivity and protein metabolism. However, lower titers of alpha-antitoxin, lysine levels and C-reactive protein content were registered in the mastitis patients treated with cephaloridin. Therefore, while recomending antibacterial drugs their effect on the immunity and protein metabolism should be taken into account and from this point of view semisynthetic penicillins are preferable in treatment of mastitis patients and semisynthetic penicillins and cephaloridin are preferable in treatment of endomyometritis patients.

• Authors: N N Kulikova, G S Minasova, F A Smekuna
• Journal: Antibiotiki (Antibiotiki) Vol. 22 Issue 4 Pg. 344-8 (Apr 1977) ISSN: 0003-5637 [Print] Russia (Federation)
• Vernacular Title: Izuchenie vliianiia polusinteticheskikh penitsillinov i tsefaloridina na pokazateli immunologicheskoĭ reaktivnosti i belkovogo obmena pri lechenii poslerodovykh infektsionnykh zabolevaniĭ.
• PMID: 883788 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Blood Proteins
• C-Reactive Protein
• Cephaloridine
• Methicillin
• Oxacillin

Topics

• Adolescent
• Adult
• Blood Proteins (metabolism)
• C-Reactive Protein (analysis)
• Cephaloridine (therapeutic use)
• Endometritis (blood, drug therapy, immunology)
• Female
• Humans
• Mastitis (blood, drug therapy, immunology)
• Methicillin (therapeutic use)
• Oxacillin (therapeutic use)
• Pregnancy
• Puerperal Infection (blood, drug therapy, immunology)