Abstract | BACKGROUND/AIMS: METHODS: In 88 female Wistar rats the biliary system was occluded by double ligation of the choledochal duct followed by retrograde injection of a mixture of prolamine/ethanole ( Ethibloc). Sixteen rats served as controls. Groups of 8-10 rats were sacrificed at days 2, 7, 14, 21, 30, 32, 35, 60 and 90 after bile duct occlusion. In the groups histological staging ( fibrosis score), determination of total liver hydroxyproline, measurement of serum procollagen type-III- peptide and routine liver function tests were performed. RESULTS: CONCLUSIONS:
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Authors | B Gerling, M Becker, J Waldschmidt, M Rehmann, D Schuppan |
Journal | Journal of hepatology
(J Hepatol)
Vol. 25
Issue 1
Pg. 79-84
(Jul 1996)
ISSN: 0168-8278 [Print] Netherlands |
PMID | 8836905
(Publication Type: Journal Article)
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Chemical References |
- Peptide Fragments
- Procollagen
- procollagen Type III-N-terminal peptide
- Hydroxyproline
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Topics |
- Animals
- Cholestasis
(complications)
- Disease Models, Animal
- Female
- Humans
- Hydroxyproline
(analysis)
- Liver Cirrhosis, Experimental
(blood, etiology)
- Peptide Fragments
(blood)
- Procollagen
(blood)
- Rats
- Rats, Wistar
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