Modulation of rhythmical slow activity, long-term potentiation and memory by muscarinic receptor agonists.

Abstract

We investigated the cholinergic modulation of hippocampal rhythmical slow activity (or theta activity), long-term potentiation and a behavioral memory task. The intravenous administration of the muscarinic receptor agonists, AF102B ((+/-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3') quinuclidine hydrochloride hemihidrate) and oxotremorine, induced rhythmical slow activity at doses of 1.0 mg/kg and 0.01 mg/kg, respectively. Long-term potentiation of population spike amplitude in the hippocampal CA1, which was induced by tetanic stimulation to the Schaffer collateral/commissural fiber, was increased by AF102B (1.0 mg/kg i.v.) and oxotremorine (0.01 mg/kg i.v.). Oral administration of AF102B and oxotremorine improved scopolamine-induced memory deficits in a passive avoidance task in mice at doses of 1.0 mg/kg and 0.2 mg/kg, respectively. The correspondence of the effective doses of muscarinic receptor agonists in these three experiments suggested the cholinergic correlation of rhythmical slow activity, long-term potentiation and memory.

• Authors: Y Iga, H Arisawa, M Ise, H Yasuda, Y Takeshita
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 308 Issue 1 Pg. 13-9 (Jul 11 1996) ISSN: 0014-2999 [Print] Netherlands
• PMID: 8836627 (Publication Type: Journal Article)

Chemical References

• Muscarinic Agonists
• Quinuclidines
• Thiophenes
• Oxotremorine
• Scopolamine
• cevimeline

Topics

• Administration, Oral
• Animals
• Avoidance Learning (drug effects)
• Dose-Response Relationship, Drug
• Electric Stimulation
• Electroencephalography (drug effects)
• Hippocampus (drug effects, physiology)
• Long-Term Potentiation (drug effects)
• Male
• Memory (drug effects)
• Mice
• Mice, Inbred Strains
• Muscarinic Agonists (pharmacology)
• Oxotremorine (administration & dosage, pharmacology)
• Quinuclidines (administration & dosage, pharmacology)
• Rats
• Rats, Wistar
• Scopolamine (pharmacology)
• Synaptic Transmission (drug effects)
• Theta Rhythm (drug effects)
• Thiophenes