Abstract |
Ebelactones A and B, natural products from Streptomyces aburaviensis are potent inhibitors of pancreatic lipase. Lipase is the key enzyme required for the absorption of dietary triglycerides (TG). Ebelactone B inhibited, in a dose-dependent manner, the intestinal absorption of fat after fat-feeding in the rat. The most effective inhibition was observed when the inhibitor was administered at 60 min prior to fat-feeding. When ebelactone B (10 mg/kg) was administered, the serum levels of TG (58%) and cholesterol (36%) were decreased. Since ebelactone B effectively inhibitors absorption of dietary fat, if may provide a promising means for prophylaxis or therapeutics of hyperlipidemia and obesity.
|
Authors | Y Nonaka, H Ohtaki, E Ohtsuka, T Kocha, T Fukuda, T Takeuchi, T Aoyagi |
Journal | Journal of enzyme inhibition
(J Enzyme Inhib)
Vol. 10
Issue 1
Pg. 57-63
( 1996)
ISSN: 8755-5093 [Print] Switzerland |
PMID | 8835930
(Publication Type: Journal Article)
|
Chemical References |
- Lactones
- Lipoproteins
- Triglycerides
- ebelactone B
- ebelactone A
- Cholesterol
- Esterases
- Lipase
|
Topics |
- Animals
- Cholesterol
(blood)
- Diet
- Esterases
(antagonists & inhibitors)
- Hydrogen-Ion Concentration
- Intestinal Absorption
(drug effects)
- Lactones
(pharmacology)
- Lipase
(antagonists & inhibitors, blood)
- Lipoproteins
(blood)
- Male
- Molecular Structure
- Pancreas
(enzymology)
- Rats
- Rats, Sprague-Dawley
- Time Factors
- Triglycerides
(blood, metabolism)
|