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Effects of ebelactone B, a lipase inhibitor, on intestinal fat absorption in the rat.

Abstract
Ebelactones A and B, natural products from Streptomyces aburaviensis are potent inhibitors of pancreatic lipase. Lipase is the key enzyme required for the absorption of dietary triglycerides (TG). Ebelactone B inhibited, in a dose-dependent manner, the intestinal absorption of fat after fat-feeding in the rat. The most effective inhibition was observed when the inhibitor was administered at 60 min prior to fat-feeding. When ebelactone B (10 mg/kg) was administered, the serum levels of TG (58%) and cholesterol (36%) were decreased. Since ebelactone B effectively inhibitors absorption of dietary fat, if may provide a promising means for prophylaxis or therapeutics of hyperlipidemia and obesity.
AuthorsY Nonaka, H Ohtaki, E Ohtsuka, T Kocha, T Fukuda, T Takeuchi, T Aoyagi
JournalJournal of enzyme inhibition (J Enzyme Inhib) Vol. 10 Issue 1 Pg. 57-63 ( 1996) ISSN: 8755-5093 [Print] Switzerland
PMID8835930 (Publication Type: Journal Article)
Chemical References
  • Lactones
  • Lipoproteins
  • Triglycerides
  • ebelactone B
  • ebelactone A
  • Cholesterol
  • Esterases
  • Lipase
Topics
  • Animals
  • Cholesterol (blood)
  • Diet
  • Esterases (antagonists & inhibitors)
  • Hydrogen-Ion Concentration
  • Intestinal Absorption (drug effects)
  • Lactones (pharmacology)
  • Lipase (antagonists & inhibitors, blood)
  • Lipoproteins (blood)
  • Male
  • Molecular Structure
  • Pancreas (enzymology)
  • Rats
  • Rats, Sprague-Dawley
  • Time Factors
  • Triglycerides (blood, metabolism)

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