Effects of cytogenin on spontaneous arthritis in MRL/1 mice and on pristane-induced arthritis (PIA) in DBA/1J mice.

Abstract

Cytogenin, 8-hydroxy-3-hydroxymethyl-6-methoxyisocoumarin, has low cytotoxicity on murine and human tumour cells in vitro. It augments or suppresses phagocytosis of macrophages and lymphocyte proliferation. It has been reported that cytogenin has a potent inhibitory effect clinically on adjuvant arthritis in Lewis rats and on type II collagen-induced arthritis in DBA/1J mice. Our experimental findings provide evidence that cytogenin has beneficial effects on spontaneous polyarthritis in MRL/1 mice and pristane-induced arthritis in DBA/1J mice. The results suggest that the mode of the anti-arthritic action of cytogenin is different from those of NSAIDs; although the precise mode of action remains unclear, cytogenin may become an excellent therapeutic agent for rheumatoid arthritis.

• Authors: C Abe, S Hirano, K Wakazono, T Mase, R Yamamoto, M Matsufuji, N Sakata, N Agata, H Iguchi, M Ishizuka
• Journal: International journal of tissue reactions (Int J Tissue React) Vol. 17 Issue 5-6 Pg. 175-80 ( 1995) ISSN: 0250-0868 [Print] Switzerland
• PMID: 8835627 (Publication Type: Journal Article)

Chemical References

• Coumarins
• Isocoumarins
• Terpenes
• cytogenin
• pristane

Topics

• Animals
• Arthritis (chemically induced, drug therapy, pathology)
• Coumarins (pharmacology)
• Isocoumarins
• Male
• Mice
• Mice, Inbred DBA
• Mice, Inbred Strains
• Terpenes