HLA-B27 and HLA-B73 polymorphism and its role on antigenicity, peptide presentation, and disease susceptibility.

Abstract

Current ideas on the structure, evolution, and disease association of HLA-B27 antigens are presented, with emphasis on the effect of HLA-B27 polymorphism on T-cell recognition and antigen-presenting properties of these molecules. The molecular relationship between HLA-B27 and HLA-B73, and its implications for a putative pathogenetic role of the later antigen are discussed.

• Authors: J A Lopez De Castro
• Journal: Clinical rheumatology (Clin Rheumatol) Vol. 15 Suppl 1 Pg. 67-71 (Jan 1996) ISSN: 0770-3198 [Print] Germany
• PMID: 8835507 (Publication Type: Journal Article, Review)

Chemical References

• HLA-B Antigens
• HLA-B27 Antigen
• HLA-B73 antigen
• Peptides

Topics

• Arthritis, Reactive (etiology, immunology)
• Disease Susceptibility (immunology)
• HLA-B Antigens (immunology)
• HLA-B27 Antigen (immunology)
• Humans
• Peptides (analysis)
• Polymorphism, Genetic (immunology)
• Spondylitis, Ankylosing (etiology, immunology)