(-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine (524W91) inhibits hepatitis B virus replication in primary human hepatocytes.

Abstract

The anti-hepatitis B virus (HBV) activity of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine (524W91) in cultures of primary human hepatocytes was examined. 524W91 was anabolized to the active 5'-triphosphate in these cells. HBV replication was equally inhibited in cultures incubated with 524W91 when the drug was added 24 h preinfection, at infection, or 24 h postinfection. 524W91 inhibited HBV replication by 50% at less than 20 nM in human hepatocytes.

• Authors: L D Condreay, J P Condreay, R W Jansen, M T Paff, D R Averett
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 40 Issue 2 Pg. 520-3 (Feb 1996) ISSN: 0066-4804 [Print] United States
• PMID: 8834915 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antiviral Agents
• Zalcitabine
• Emtricitabine
• Racivir

Topics

• Antiviral Agents (pharmacology)
• Blotting, Southern
• Cells, Cultured
• Emtricitabine (analogs & derivatives)
• Hepatitis B virus (drug effects, physiology)
• Humans
• Liver (drug effects, virology)
• Time Factors
• Virus Replication (drug effects)
• Zalcitabine (analogs & derivatives, pharmacology)