| Abstract | Liposomes are useful drug carriers. In this study, adenosine triphosphate (ATP) was entrapped in liposomes (Lip-ATP). Anesthetized rats were given Lip-ATP (5 mg/kg as ATP), free ATP (5 mg/kg) or saline (control group) during stabilization. Then, the rats were exposed to 30 min of hypovolemic shock and 30 min of reperfusion. Administration of Lip-ATP significantly improved hepatic blood flow during shock (13.2 +/- 1.7 ml/min/100 g tissue in the Lip-ATP group vs. 9.4 +/- 2.2, in the control group, and 8.9 +/- 2.9 in the free ATP group) and during reperfusion (20.9 +/- 2.3, 16.3 +/- 2.2, and 16.2 +/- 1.8 ml/min/100 g tissue, respectively). The serum levels of hepatic enzymes (ALT, AST and LDH) were significantly lower in the Lip-ATP group after reperfusion when compared with the control and free ATP groups. Administration of Lip-ATP also produced the best recovery of hepatic ATP level. These findings indicate that Lip-ATP increased hepatic blood flow during shock and reperfusion, presumably by improving the energy charge and metabolism of the hepatocytes. Thus, Lip-ATP appears to be a useful agent for liver injury induced by hypovolemic shock. |
| Authors | H Konno, A F Matin, Y Maruo, S Nakamura, S Baba
(Affiliation: Second Department of Surgery, Hamamatsu University School of Medicine, Japan.)
|
| Journal | European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes
(Eur Surg Res)
Vol. 28
Issue 2
Pg. 140-5
( 1996)
ISSN: 0014-312X SWITZERLAND |
| PMID | 8834372
(Publication Type: Journal Article)
|
| Chemical References |
- Liposomes
- Adenosine Triphosphate
- L-Lactate Dehydrogenase
- Aspartate Aminotransferases
- Alanine Transaminase
|
| Topics |
- Adenosine Triphosphate
(administration & dosage)
- Alanine Transaminase
(metabolism)
- Animals
- Aspartate Aminotransferases
(metabolism)
- Blood Flow Velocity
- Infusions, Intravenous
- L-Lactate Dehydrogenase
(metabolism)
- Liposomes
(metabolism)
- Liver
(metabolism, pathology, physiopathology)
- Male
- Rats
- Rats, Sprague-Dawley
- Reperfusion
- Shock
(drug therapy, metabolism, pathology)
|
