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Tetrasomy 8 and t(1;11)(p32;q24) in acute myelo-monocytic leukemia with extensive leukemic cutaneous involvement.

Abstract
We report a case of tetrasomy 8 in a patient suffering from acute myelomonocytic leukemia with extensive leukemic cutaneous infiltration. In all metaphases analyzed t( I;11)(p32;q24) was concomitantly observed. Similarly to other cases with tetrasomy 8, the patient showed monocytic involvement and poor response to chemotherapy. We conclude that this kind of cytogenetic aberration is associated with distinct morphologic and clinical features.
AuthorsF Ferrara, D Cancemi, P Friso, M Gaglione, A Picardi, L Rossi, M Scognamiglio
JournalLeukemia & lymphoma (Leuk Lymphoma) Vol. 20 Issue 5-6 Pg. 513-5 (Feb 1996) ISSN: 1042-8194 [Print] United States
PMID8833413 (Publication Type: Case Reports, Journal Article)
Topics
  • Aged
  • Aneuploidy
  • Chromosomes, Human, Pair 1 (ultrastructure)
  • Chromosomes, Human, Pair 11 (ultrastructure)
  • Chromosomes, Human, Pair 8
  • Fatal Outcome
  • Female
  • Humans
  • Karyotyping
  • Leukemia, Myelomonocytic, Acute (genetics, pathology)
  • Leukemic Infiltration
  • Male
  • Skin (pathology)
  • Translocation, Genetic

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