CD30 ligand, a member of the TNF ligand superfamily, with growth and activation control CD30+ lymphoid and lymphoma cells.

Abstract

Hodgkin disease (HD) is characterized by the presence of a small number (usually <1% of total tumor mass) of the typical Hodgkin and Reed-Sternberg (H-RS) cells in a hyperplastic background of normal reactive lymphocytes, plasma cells, histiocytes, neutrophils, eosinophils, and stromal cells. HRS cells produce various cytokines, growth factors, and express cytokine receptors and activation antigens, implying a predominant role for these molecules in the pathophysiology of Hodgkin disease. HD may therefore be regarded as a tumor of cytokine producing cells. The CD30 antigen has been characterized as a marker for cultured and primary Hodgkin and Reed-Sternberg cells, and was found to be overexpressed in Hodgkin disease and a subgroup of non-Hodgkin lymphomas including large cell anaplastic lymphomas and Burkitt lymphomas. The molecular cloning of the CD30 antigen revealed that CD30 is a member of the tumor necrosis factor/nerve growth factor receptor superfamily. The cloning of the cognate for CD30, currently termed CD30 ligand, confirmed that the CD30 antigen functions as a cytokine receptor. Recombinant CD30 ligand is a membrane-bound protein with pleiotropic biological activities for different CD30+ lymphoma types, but also for the immune system, mainly T cells. CD30L belongs to the emerging tumor necrosis factor ligand superfamily. The CD30-CD30 ligand interaction could have a critical pathophysiological role in malignant lymphomas, particularly Hodgkin disease, large cell anaplastic lymphomas and Burkitt lymphomas, and is also involved in activation and functioning of the T cell-dependent immune system.

• Authors: Gruss H-J, F Herrmann
• Journal: Leukemia & lymphoma (Leuk Lymphoma) Vol. 20 Issue 5-6 Pg. 397-409 (Feb 1996) ISSN: 1042-8194 [Print] United States
• PMID: 8833395 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Biomarkers, Tumor
• CD30 Ligand
• Cytokines
• Ki-1 Antigen
• Membrane Glycoproteins
• Neoplasm Proteins
• Receptors, Cytokine
• Recombinant Fusion Proteins
• TNFSF8 protein, human

Topics

• Biomarkers, Tumor
• CD30 Ligand
• Cell Differentiation
• Cell Division
• Chromosomes, Human, Pair 1 (genetics)
• Chromosomes, Human, Pair 9 (genetics)
• Cloning, Molecular
• Cytokines (physiology)
• Gene Expression Regulation, Neoplastic
• Hodgkin Disease (genetics, metabolism, pathology)
• Humans
• Ki-1 Antigen (genetics, physiology)
• Lymphocyte Activation
• Lymphocyte Subsets (cytology, immunology)
• Lymphoma (genetics, metabolism)
• Membrane Glycoproteins (genetics, physiology)
• Multigene Family
• Neoplasm Proteins (genetics, physiology)
• Neoplasms (genetics, metabolism)
• Receptors, Cytokine (genetics)
• Recombinant Fusion Proteins (metabolism, pharmacology)
• Reed-Sternberg Cells (metabolism)
• Tumor Cells, Cultured